The San Francisco 49ers lose CB Will James (high ankle sprain) and rookie PR/KR/WR Kyle Williams (sprained big toe) for a while.  James is likely to miss the next 4-6 weeks while Williams is likely out six weeks.  James had 1 tackle and 1 interception against the Colts this weekend and he is expected to have a big role for the Niners this year.  Williams returned 1 punt for 36 yards, 2 kickoff for 42 yards and he caught 1 pass for 8 yards in the pre-season opener.  He was going to have to fight for his roster spot so this injury might have cost him a job with the Niners.